Efficacy and Safety of Aflibercept Therapy for Diabetic Macular Edema: A Systematic Review and Meta-Analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36147265/
1 Faculty of Medicine, McGill University, Montreal, Canada. 2 Department of Ophthalmology, Faculty of Medicine, McGill University, Montreal, Canada. 3 Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal,...
Conclusions: Aflibercept is a safe and effective therapy option for DME in the clinical setting, performing superiorly to laser photocoagulation. Evidence regarding comparisons with bevacizumab, ranibizumab, and dexamethasone is mixed and limited.
Short-term outcomes of switching to brolucizumab in japanese patients with neovascular age-related macular degeneration - Japanese Journal of Ophthalmology
Source : https://link.springer.com/article/10.1007/s10384-022-00940-1
Purpose To evaluate the outcomes of a 6-month follow-up after switching to brolucizumab from aflibercept to treat neovascular age-related macular degeneration (AMD) in Japanese patients. Study design Retrospective observational study....
Conclusion: Switching to brolucizumab from aflibercept using a TAE regimen might be effective for maintaining functional outcomes and extending intervals in Japanese patients with AMD.
Hyperreflective Membrane at the Vitreoretinal Interface in Diabetic Macular Edema: A Finding in Ultra-High-Resolution Optical Coherence Tomography - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36149646/
1 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 2 Department of Ophthalmology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan. 3 Clinical Research Institute, National...
Conclusion/Relevance: Detecting subtle vitreoretinal interface (VRI) findings, such as a posterior hyaloid membrane, is difficult with conventional retinal imaging. We compared ultra-high-resolution spectral domain optical coherence tomography (UHR-SD-OCT) with standard-resolution OCT (SD-OCT) for the imaging of VRI abnormalities in diabetic...
Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy: Longitudinal Evaluation in Age-Related Macular Degeneration
Source : https://www.aaojournal.org/article/S0161-6420(22)00691-1/fulltext
To examine the association between incomplete retinal pigment epithelial and outer retinal atrophy (iRORA) on optical coherence tomography (OCT) imaging and the subsequent risk of developing geographic atrophy (GA) defined...
Conclusions: In this cohort, iRORA is a significant risk factor for GA development, but its association with GA development appears to be accounted for by the development of the specific features that define nGA. Whilst requiring replication, these findings provide useful guidance on the relative utility of nGA and iRORA as risk factors for GA...
OCT Analysis of Retinal Pigment Epithelium in Myopic Choroidal Neovascularization: Correlation Analysis with Different Treatments - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36078952/
Objective : The objective of this study was to analyze the status of the retinal pigment epithelium (RPE) by means of the spectral domain optical coherence tomography (SD-OCT) overlying the...
Conclusions: Our results showed that the size of myopic neovascular lesion influences the development of a uniform RPE above the lesion and therefore the disease prognosis. The presence of uniform RPE was found to be extremely important in the follow-up of patients with myopic CNV, as it influences the duration of the disease and the number of...