Progress of Anti-VEGF Agents for Retinal Angiogenesis | DDDT
Currently, the most common blinding fundus diseases worldwide mainly include age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal vein occlusions (RVO), and retinopathy of prematurity (ROP), which cause vision loss...
Conclusion/Relevance: At present, two sustained-release materials are being tested in clinical research, and although basic research shows the strong therapeutic application prospects of extended-release drugs, its challenges mainly involve the discrepancy between the release rates in vitro and the efficiency of the drugs in vivo. Briefly,...
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Retina Health Connect3yrKey Points • Source: Drug Design, Development and Therapy • Relevance: “Currently, the treatment for ocular neovascular diseases, including diabetic macular edema (DME) and age-related macular degeneration (AMD), mainly involves repeated intravitreal injection of Show More
Original research: Associations with visual acuity outcomes after 12 months of treatment in 9401 eyes with neovascular AMD
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240889/
Original research Collaborators: Real world AMD treatment outcomes EMR User Group, C Santiago, H Devonport, C Bailey, I Dias, P Scanlon, L Downey, I Pearce, H Saedon, SJ Talks, B...
Conclusions: Even after adjustment for other variables, variation in acuity outcomes after NvAMD treatment within the NHS remains. Meaningful comparison of outcomes between different providers requires adjustment for a range of baseline characteristics, not visual acuity alone. Identifying best practice at sites with better outcomes and adapting...
A Cross-Sectional Study of Various Imaging and Biochemical Biomarkers | OPTH
Diabetes is a metabolic disorder affecting 463 million people globally and 77 million people in India. When ophthalmic manifestations are considered, DR is taking center stage today. DR is one...
Conclusion: The essential biochemical biomarkers such as serum urea levels and DRT and ERM may be considered an important imaging biomarker for the advanced stage of DR.
Central posterior hyaloidal fibrosis - A novel optical coherence tomography feature associated with choroidal neovascular membrane
Source : https://www.sciencedirect.com/science/article/pii/S2451993622004558?via=ihub
To describe a novel optical coherence tomography (OCT) finding at the vitreomacular interface (VMI), and report its association with advanced choroidal neovascularisation (CNV). Optical coherence tomography (OCT) scans performed at...
Conclusions and Importance: Central Posterior Hyaloidal Fibrosis (CPHF) is a newly reported OCT finding associated with advanced CNV, which may represent a possible profibrotic influence of a choroidal neovascular membrane to the overlying posterior hyaloid adhesion.
Risk factors for myopic choroidal neovascularization-related macular atrophy after anti-VEGF treatment
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0273613
Purpose The study aimed to evaluate risk factors for macular atrophy (MA) associated with myopic choroidal neovascularization (mCNV) during long-term follow-up after intravitreal anti-vascular endothelial growth factor (VEGF) treatment in...
Conclusions: In mCNV eyes treated with intravitreal anti-VEGF agents, older age and greater mCNV size at baseline were risk factors for the development of MA during long-term follow-up, which was associated with a poor visual prognosis.