PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models - Cell Communication and Signaling
Source : https://biosignaling.biomedcentral.com/articles/10.1186/s12964-022-00973-6
Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated macrophages recruited to the injured eyes greatly contribute to the...
Conclusion: The PGE2/EP1R signalling network serves as a potential therapeutic target for CNV of the wet-type AMD.
Personalized Approach in Treatment of Neovascular Age-Related Macular Degeneration - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36143241/
doi: 10.3390/jpm12091456. 1 Department of Ophthalmology, ENT and Maxillofacial Surgery, Medical University-Pleven, 5800 Pleven, Bulgaria. 2 Department of Ophthalmology, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy. 3 Department of Ophthalmology,...
Conclusion: The analysis of our results could be used as prognostic markers for the evolution of the disease and as a basis for new treatment strategies, depending on the naïve NVM morphologic type.
Mental health and visual acuity in patients with age-related macular degeneration - BMC Ophthalmology
Source : https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-022-02602-9
Background Visual acuity (VA) loss has been associated with depression in patients with age-related macular degeneration (AMD). However, previous studies did not incorporate subgroups of AMD when correlating VA and...
Conclusion: There is a significant association between mental health questionnaire scores and AMD classification, as well as VA in both the better and worse-seeing eyes in patients with AMD. It is important for clinicians to recognize feelings of worry/ frustration in these patients, so they can be appropriately referred, screened, and treated...
HTRA1 Regulates Subclinical Inflammation and Activates Proangiogenic Response in the Retina and Choroid - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36142120/
1 Singapore National Eye Centre, Singapore Eye Research Institute, 11 Third Hospital Ave, Singapore 168751, Singapore. 2 Molecular and Cellular Biology Division, National Institute of Sensory Organs, National Hospital Organization...
Conclusion: Choroidal explants of the old CAG-HtrA1 Tg mice demonstrated an increased area of sprouting (p < 0.05). Signs of subclinical inflammation was observed in CAG-HtrA1 Tg mice. Such subclinical inflammation may have resulted in increased RPE cell activation and angiogenic potential.
Characteristics of age-related macular degeneration showing a poor response to three loading doses of anti-VEGF - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36161992/
Purpose: To analyze the clinical features of refractory age-related macular degeneration (AMD) patients associated with the response to three consecutive loading doses of anti-vascular endothelial growth factor (VEGF). Methods: A...
Conclusions: A thicker choroid and the presence of loops and a peripheral arcade were significantly associated with a poorer response to three loading anti-VEGF injections in typical exudative AMD patients.