Predictive impact of optical coherence tomography biomarkers in anti-vascular endothelial growth factor resistant macular edema treated with dexamethasone implant
Source : https://www.sciencedirect.com/science/article/abs/pii/S1572100022004549?via=ihub
OCT allows for qualitative and quantitative assessment of the many structural changes that occur in macular edema. * Structural changes seen on OCT may be predictive of response to treatment...
Conclusions: DEX implant therapy resulted in a satisfactory reduction in CFT in patients with DME and RVO. The presence of HRF and SMD is a negative predictor of recurrence in CFT in short term. DEX implant therapy resulted in satisfactory improvement in SMD.
Intravitreal dexamethasone implant has better retinal perfusion than anti-vascular endothelial growth factor treatment for macular edema secondary to retinal vein occlusion: a five-year real-world study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36215955/
Purpose: To investigate the long-term effect of intravitreal dexamethasone (DEX) implant and anti-vascular endothelial growth factor (VEGF) injection on macular edema (ME) secondary to retinal vein occlusion (RVO) in a...
Conclusion: Compared with the anti-VEGF treatment, the DEX treatment had advantages in maintaining retinal perfusion in patients with RVO.
Efficacy of single-dose intravitreal dexamethasone implantation for retinal vein occlusion patients with refractory macular edema: A systematic review and meta-analysis
Source : https://www.frontiersin.org/articles/10.3389/fphar.2022.951666/full
Purpose: To assess the functional and anatomical consequences of single-dose dexamethasone (DEX) implants for the treatment of refractory macular edema (ME) secondary to retinal vein occlusion (RVO) after anti-vascular endothelial...
Conclusion: This meta-analysis showed that RVO patients with refractory ME could benefit significantly from switching therapy to DEX implantation, with efficacy lasting 6 months after a single-dose application. Intravitreal DEX implantation is a safe and effective option for refractory cases.
Long-Term Retinal Vascular Changes in Age-Related Macular Degeneration Measured Using Optical Coherence Tomography Angiography - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36239679/
Background and objective: To determine if age-related macular degeneration (AMD) status affects longitudinal retinal vessel changes. Patients and methods: Retrospective, cohort study of 125 eyes (75 patients) with AMD, following...
Conclusion: AMD eyes with GA undergo more rapid loss of retinal vessel density and FAZ enlargement over 2 years, suggesting a relationship between the retinal vasculature and AMD pathophysiology.
Therapeutic Approaches for Age-Related Macular Degeneration - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36233066/
Damage to the retinal pigment epithelium, Bruch's membrane and/or tissues underlying macula is known to increase the risk of age-related macular degeneration (AMD). AMD is commonly categorized in two distinct...
Conclusion: In this work, we revised the recent challenges encountered in the treatment of different forms of AMD, innovative nanoformulations, 3D bioprinting, and techniques to monitor the progress.