Regulation of oxidative stress and inflammatory responses in human retinal pigment epithelial cells - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36343937/
Age-related macular degeneration (AMD) is an eye disease, which causes impaired vision that can lead to blindness. The incidence of AMD increases with age. Retinal pigment epithelial (RPE) cells maintain...
Conclusions: Conclusions/Relevance: Hydroquinone induced an NLRP3-independent IL-18 release and NLRP3 accumulation inside the IL-1α-primed cells. Resvega treatment reduced the extent of hydroquinone-induced ROS production and NLRP3 inflammasome activation evoked by impaired protein clearance. Thus, Resvega alleviated hydroquinone- and impaired...
Triamcinolone Acetonide Suprachoroidal Injectable Suspension for Uveitic Macular Edema: Integrated Analysis of Two Phase 3 Studies - Ophthalmology and Therapy
Source : https://link.springer.com/article/10.1007/s40123-022-00603-x
Introduction Macular edema, a common complication of uveitis, may result in vision loss. The aim of this analysis was to report integrated phase 3 trial data for triamcinolone acetonide injectable...
Conclusions: "Conclusion: In this integrated analysis utilizing strict inclusion criteria, SCS-TA was found effective in the treatment of patients with macular edema associated with noninfectious uveitis and was generally well tolerated."
Current and Novel Therapeutic Approaches for Treatment of Neovascular Age-Related Macular Degeneration - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36358978/
Age-related macular degeneration AMD is one of the leading causes of blindness in the elderly population. An advanced form of AMD known as neovascular AMD (nAMD) is implicated as the...
Conclusions: While Anti-VEGF agents have provided a favorable prognosis for nAMD, they are associated with a substantial financial burden for patients and the healthcare system, due to their high cost as well as the need for frequent repeat treatments and visits. Emerging therapies and studies aim to extend the intervals between required...
Factors associated with reduced visual acuity in myopes with and without ocular pathologies after optical correction - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36239084/
doi: 10.1111/opo.13059. Online ahead of print. 1 Myopia Research Lab, Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India. 2 Infor Myopia Centre, Brien Holden Institute...
Conclusions: Even after full optical correction, both refractive components and pathologic myopia lesions can independently cause reduced visual acuity, regardless of the degree of myopia."
Risk Factors and Treatment Strategy for Retinal Vascular Occlusive Diseases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36362567/
Retinal occlusive diseases are common diseases that can lead to visual impairment. Retinal artery occlusion and retinal vein occlusion are included in the clinical entity, but they have quite different...
Conclusions: In this review, we summarize the current findings and advances in knowledge regarding retinal occlusive diseases, particularly focusing on recent studies, in order to provide an update for a better understanding of its pathogenesis.