Molecular Mediators and Regulators of Retinal Angiogenesis
Source : https://www.tandfonline.com/doi/abs/10.1080/08820538.2022.2152706?journalCode=isio20
ABSTRACT Retinal neovascularization is the major cause of vision loss that affects both adults and young children including premature babies. It has been a major pathology in several retinal diseases...
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Conclusions: This review highlights the potential regulatory mechanism/pathways involved in retinal neovascularization and its implications in retinal diseases and for identifying new drug targets.
Ganglion cell complex changes in wet AMD patients treated with anti-VEGF intravitreal injections according to a treat-and-extend protocol
Source : https://www.canadianjournalofophthalmology.ca/article/S0008-4182(22)00370-2/fulltext
To analyze changes in ganglion cell complex (GCC) thickness in wet age-related macular degeneration (AMD) patients receiving intravitreal injections. Retrospective cohort study involving 46 eyes at a single tertiary ophthalmology...
Conclusions: Study results suggest that that there is no significant GCC thinning in wet AMD patients following a treat-and-extend regimen over 3 years.
Recent Advances in Proteomics-Based Approaches to Studying Age-Related Macular Degeneration: A Systematic Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36499086/
Age-related macular degeneration (AMD) is a common ocular disease characterized by degeneration of the central area of the retina in the elderly population. Progression and response to treatment are influenced...
Conclusions: Although anti-vascular endothelial growth factor (anti-VEGF)-based therapy has been crucial in the treatment of neovascular AMD, it is necessary to deepen our understanding of the underlying disease mechanisms to move forward to next-generation therapies for later-stage forms of this multifactorial disease.
Recent trends in anti-vascular endothelial growth factor intravitreal injections: a large claims database study in Japan - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36508060/
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Conclusions: These findings can be used as a benchmark for the clinical practice of anti-VEGF therapy.
Dietary Intake and Diabetic Retinopathy: A Systematic Review of the Literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36501054/
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus. The evidence connecting dietary intake and DR is emerging, but uncertain. We conducted a systematic review to comprehensively summarize...
Conclusions: The general recommendation for nutritional counseling to manage diabetes may be beneficial to prevent DR risk, but prospective studies in diverse diabetic populations are needed to confirm our findings and expand clinical guidelines for DR management.