Aqueous microRNA profiling in age-related macular degeneration and polypoidal choroidal vasculopathy by next-generation sequencing - Scientific Reports
Source : https://www.nature.com/articles/s41598-023-28385-7
Although many studies demonstrated the differences of clinical features, natural course, and response to treatment between typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV), differential microRNAs (miRNAs) expression...
Conclusions: The differential expression profiles and target gene regulation networks of AH miRNAs may contribute to the development of different pathological phenotypes in typical AMD and PCV. The results of this study provide novel insights into the pathogenesis, associated prognostic biomarkers, and therapeutic targets in AMD and PCV.
Protective effects of Panax ginseng berry extract on blue light-induced retinal damage in ARPE-19 cells and mouse retina
Source : https://www.sciencedirect.com/science/article/pii/S1226845322000550?via=ihub
Age-related macular degeneration (AMD) is a significant visual disease that induces impaired vision and irreversible blindness in the elderly. However, the effects of ginseng berry extract (GBE) on the retina...
Conclusions: GBE could be a potential agent to prevent dry AMD and progression to wet AMD.
The Role of Inflammation in Age-Related Macular Degeneration: Updates and Possible Therapeutic Approaches - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36650098/
Age-related macular degeneration (AMD) is a common retinal disease characterized by complex pathogenesis and extremely heterogeneous characteristics. Both in "dry" and "wet" AMD forms, the inflammation has a central role...
Conclusions: The main goal of the present paper is to provide an updated overview of the pathogenic contribution of inflammation in AMD and the possible therapeutic perspectives.
The Impact of Residual Retinal Fluid Following Intravitreal Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema and Macular Edema Secondary to Retinal Vein Occlusion: A Systematic Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36626212/
The association between residual retinal fluid and visual acuity for diabetic macular edema (DME) and macular edema (ME) secondary to retinal vein occlusion (RVO) is not well established. We conducted...
Conclusions: Our systematic review of five studies and 613 eyes found that in general, there is a lack of literature on the association of residual retinal fluid and visual acuity outcomes in the setting of ME secondary to RVO and DME. However, the limited evidence suggests that it may be worthwhile pursuing aggressive fluid resolution in...
Current Treatments and Innovations in Diabetic Retinopathy and Diabetic Macular Edema - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36678750/
Diabetic retinopathy (DR) is one of the leading causes of blindness worldwide. Multiple treatment options have been used over time to attempt to modify the natural progression of the disease...
Conclusions: This manuscript aims to provide a comprehensive review of current treatments, including the main drugs used in diabetic pathologic manifestations, as well as new therapeutic alternatives, such as extended-release intraocular devices.