Short-term effects of intravitreal anti-vascular endothelial growth factor agents on body weight and multiple systems after treatment for retinopathy of prematurity
Source : https://www.frontiersin.org/articles/10.3389/fped.2022.1077137/full
ObjectivesThis study's goal was to assess the short-term effect on body weight and multiple systems following intravitreal injections of ranibizumab and aflibercept for retinopathy of prematurity (ROP).MethodsWe retrospectively assessed infants...
Conclusions: IVR and IVA could have a short-term inhibitive effect on body weight gain in infants after treatment for ROP, whereas there is no significant impact on other systems.
Mechanism of circular RNA-mediated regulation of L-DOPA to improve wet age-related macular degeneration
Source : https://www.sciencedirect.com/science/article/abs/pii/S0378111923000884?via=ihub
This study aimed to investigate the effect and mechanism of levodopa (L-DOPA) in the treatment of age-related macular degeneration (AMD). A wet AMD cell model was created via CoCl 2...
Conclusions: Circ-SGMS1 is of immense significance in the AMD treatment mechanism of L-DOPA. Overexpression of circ-SGMS1 may alleviate wet AMD by inhibiting HIF-1a and THBS1 expression.
Emerging Treatment Options for GA Secondary to AMD | OPTH
Age-related macular degeneration (AMD) is a multifactorial, degenerative disease associated with progressive vision loss, and is more common in developed nations but is prevalent in all countries. AMD is categorized...
Conclusions: As investigators continue to study various treatment options for GA, ophthalmologists must carefully consider all treatment options and safety outcomes to determine the most efficacious modality. Improving the understanding of the pathophysiology of GA secondary to dry AMD, for patients, optometrists, and ophthalmologists alike, may...
Syringe Design and Filling Technique Affect Accuracy of Anti-VEGF Intravitreal Injections - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36729828/
Intravitreal injections using 1.0 mL syringes are less accurate than using the ranibizumab pre-filled syringe, which has a low volume and low dead-space plunger design. The variability in volume output...
Conclusions: Intravitreal injections using 1.0 mL syringes are less accurate than using the ranibizumab pre-filled syringe, which has a low volume and low dead-space plunger design. The variability in volume output may result in less predictable treatment response, especially in cases of underdosing, which were more common with the ranibizumab...
Biosimilars for retinal diseases: United States-Europe awareness survey (Bio-USER - survey) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36726203/
The Bio-USER survey revealed that while the majority of retinal physicians need additional information regarding the safety, efficacy and immunogenicity when making clinical decisions regarding their use. Retinal physicians from...
Conclusions: The Bio-USER survey revealed that while the majority of retinal physicians need additional information regarding the safety, efficacy and immunogenicity when making clinical decisions regarding their use. Retinal physicians from US are more comfortable in continuing to use off-label bevacizumab compared to physicians from Europe....