Systemic Blood Proteome Patterns Reflect Disease Phenotypes in Neovascular Age-Related Macular Degeneration - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37373474/
There is early evidence of extraocular systemic signals effecting function and morphology in neovascular age-related macular degeneration (nAMD). The prospective, cross-sectional BIOMAC study is an explorative investigation of peripheral blood...
Conclusion: So far unconsidered systemic signals in the peripheral blood proteome contribute to the clinically observed phenotype of nAMD, which should be examined in future translational research on AMD.
Stages, pathogenesis, clinical management and advancements in therapies of age-related macular degeneration - International Ophthalmology
Source : https://link.springer.com/article/10.1007/s10792-023-02767-2
Age-related macular degeneration (AMD) is a retinal degenerative disorder prevalent in the elderly population, which leads to the loss of central vision. The disease progression can be managed, if not...
Conclusions/Relevance: This review focuses on the molecular mechanism of the disease, model systems (both cellular and animal) used in studying AMD, the list of various regenerative therapies and the current treatments available. The article also highlights on the recent clinical trials using regenerative therapies and management of the...
Two-year Clinical Outcomes Following Photodynamic Acute... : RETINA
who received half-fluence PDT and had a 2-year follow-up. Patients were classified into 2 groups based on whether they had had PAEM at 3 days after treatment (PAEM+, n=22; ≥50...
Conclusions: Patients with cCSCR with and without PAEM presented similar results at 2 years in terms of BCVA gain, SRF reduction and complication rate.
Scale-adaptive model for detection and grading of age-related macular degeneration from color retinal fundus images - Scientific Reports
Source : https://www.nature.com/articles/s41598-023-35197-2
Age-related Macular Degeneration (AMD), a retinal disease that affects the macula, can be caused by aging abnormalities in number of different cells and tissues in the retina, retinal pigment epithelium,...
Conclusion: In this study, we have proposed an integrated model for scaling input images and distinguishing between normal retinas and AMD grades using color fundus images. Our approach involves two stages.
Impact of an immersive, interactive medical education initiative on guideline-based retinal disease management knowledge/competence and effectual practice change - BMC Ophthalmology
Source : https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-023-03034-9
Background Retinal diseases, including wet or dry age-related macular degeneration, diabetic macular edema, and diabetic retinopathy (DR), are underdiagnosed and undertreated in the United States. Clinical trials support the effectiveness...
Conclusions: This modular, interactive, immersive CE initiative resulted in significant knowledge/competence gains among retinal disease care providers and changes in practice-related treatment behaviors (i.e., appropriate consideration and greater incorporation of guideline-recommended anti-VEGF therapies) among participating...