The HIT Study-The Hydroxychloroquine Effect in the Treatment of Patients with Age-Related Macular Degeneration: A Randomized Controlled Trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36984552/
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Conclusion: Among patients with AMD, visual deterioration, the growth and the amount of drusen formation at two years after treatment initiation was less among those treated with HCQ than with a placebo. In this study, there was a negative association between HCQ treatment and wet AMD development.
Graph Attention U-Net for Retinal Layer Surface Detection and Choroid Neovascularization Segmentation in OCT Images
Source : https://ieeexplore.ieee.org/document/10032187
Choroidal neovascularization (CNV) is a typical symptom of age-related macular degeneration (AMD) and is one of the leading causes for blindness. Accurate segmentation of CNV and detection of retinal layers...
Conclusions/Relevance: Experiment results show that the proposed model outperformed the competing methods for retinal layer surface detection and CNV segmentation and achieved new state of the arts on the datasets.
Comprehensive review of glucagon-like peptide 1 receptor agonist treatment on the risk of cardiovascular outcomes and retinopathy as diabetic complications - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37013752/
Cardiovascular and microvascular disorders are serious complications of diabetes. Intensive glucose control is believed to hinder the pathological progression of these complications. In this review, we focus on the risk...
Conclusions/Relevance: Topical administration of GLP-1RAs induces direct retinal neuroprotection against DR by multiple mechanisms, such as preventing both neurodysfunction and retinal neurodegeneration; relieving the disruption of the blood-retinal barrier and associated vascular leakage, and inhibiting oxidative stress, inflammatory action,...
ILUVIEN® for the treatment of retinal conditions | DDDT
With rare but serious complications associated with intravitreal injections, such as endophthalmitis, retinal detachment, and vitreous haemorrhage, sustained-release corticosteroid implants, have emerged to reduce the frequency of repeated intravitreal injections....
Relevance: The aim of this review is to describe the special pharmacological properties of Iluvien and display the outcomes of the most important clinical trials and real-world studies regarding its efficacy and safety for the management of the above retinal disorders.
Proteotranscriptomic analyses reveal distinct interferon-beta signaling pathways and therapeutic targets in choroidal neovascularization
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2023.1163739/full
AimTo investigate the molecular mechanism underlying the onset of choroidal neovascularization (CNV).MethodsIntegrated transcriptomic and proteomic analyses of retinas in mice with laser-induced CNV were performed using RNA sequencing and tandem...
Conclusions: This study demonstrates that the occurrence of CNV might be associated with the dysfunction of immune and inflammatory processes and that IFN-β could serve as a potential therapeutic target.