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Efficacy and mechanism of anti-vascular endothelial growth factor drugs for diabetic macular edema patients

Efficacy and mechanism of anti-vascular endothelial growth factor drugs for diabetic macular edema patients

Source : https://www.wjgnet.com/1948-9358/full/v13/i7/532.htm

Diabetic macular edema (DME), which manifests clinically as visual impairment, is a common complication of diabetes[ 1- 3]. Long-term high blood glucose is the basis of DME, as it causes increased endothelial cell permeability in the tight junctions of retinal capillaries, allowing protein and fluid to accumulate in the area of the macula, resulting in macular edema.


Conclusion: Anti-VEGF drugs can effectively improve CMT and SFCT, without affecting microcirculation, thus providing an effective and safe treatment for patients with DME.