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Reduction of Laser-Induced Choroidal Neovascularization in Mice With Erythropoietin RNA Interference

Reduction of Laser-Induced Choroidal Neovascularization in Mice With Erythropoietin RNA Interference

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351596/

Wenjuan Lv, 1 , * Wen Chen, 1 , 2 , * Shaofen Huang, 1 Yanxuan Xu, 1 Jia-Jian Liang, 1 Yuqian Zheng, 1 Shaowan Chen, 1 Shao-Lang Chen, 1 Tsz Kin Ng, 1 , 2 , 3 and Haoyu Chen 1 The purpose of this study was to evaluate the pathological involvement of erythropoietin (EPO) in experimental choroidal neovascularization (CNV) and its association with neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) in the Chinese population.


Conclusions: This study revealed the promotion of human endothelial cell tube formation in vitro and choroid sprouting ex vivo by EPO, and the reduction of laser-induced CNV in vivo by Epo RNA interference.