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Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration

Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration

Source :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244395/

Age-Related Macular Degeneration (AMD) is a bilateral ocular condition resulting in irreversible vision impairment caused by the progressive loss of photoreceptors in the macula, a region at the center of the retina. The progressive loss of photoreceptor is a key feature of dry AMD but not always wet AMD, though both forms of AMD can lead to loss of vision.


Relevance: This study provides new observations for retina age clocks and suggests new applications for monitoring in vitro neuronal differentiation. These clocks could provide useful markers for AMD monitoring and possible intervention, as well as potential targets for in vitro screens.