Purpose The study aimed to evaluate risk factors for macular atrophy (MA) associated with myopic choroidal neovascularization (mCNV) during long-term follow-up after intravitreal anti-vascular endothelial growth factor (VEGF) treatment in ..... see more
1 Faculty of Medicine, McGill University, Montreal, Canada. 2 Department of Ophthalmology, Faculty of Medicine, McGill University, Montreal, Canada. 3 Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, ..... see more
Purpose To evaluate the outcomes of a 6-month follow-up after switching to brolucizumab from aflibercept to treat neovascular age-related macular degeneration (AMD) in Japanese patients. Study design Retrospective observational study. ..... see more
1 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 2 Department of Ophthalmology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan. 3 Clinical Research Institute, National ..... see more
Conclusion/Relevance: Detecting subtle vitreoretinal interface (VRI) findings, such as a posterior hyaloid membrane, is difficult with conventional retinal imaging. We compared ultra-high-resolution spectral domain optical coherence tomography (UHR-SD-OCT) with standard-resolution OCT (SD-OCT) for the imaging of VRI abnormalities in diabetic...
To examine the association between incomplete retinal pigment epithelial and outer retinal atrophy (iRORA) on optical coherence tomography (OCT) imaging and the subsequent risk of developing geographic atrophy (GA) defined ..... see more
Conclusions: In this cohort, iRORA is a significant risk factor for GA development, but its association with GA development appears to be accounted for by the development of the specific features that define nGA. Whilst requiring replication, these findings provide useful guidance on the relative utility of nGA and iRORA as risk factors for GA...
Objective : The objective of this study was to analyze the status of the retinal pigment epithelium (RPE) by means of the spectral domain optical coherence tomography (SD-OCT) overlying the ..... see more
Conclusions: Our results showed that the size of myopic neovascular lesion influences the development of a uniform RPE above the lesion and therefore the disease prognosis. The presence of uniform RPE was found to be extremely important in the follow-up of patients with myopic CNV, as it influences the duration of the disease and the number of...
The META-Analysis of Pathologic Myopia Study group proposed a new classification system for myopic maculopathy (MM) with pathologic myopia (PM) defined as MM equal to/more serious than diffuse atrophy or ..... see more
Relevance: The META-Analysis of Pathologic Myopia Study group proposed a new classification system for myopic maculopathy (MM) with pathologic myopia (PM) defined as MM equal to/more serious than diffuse atrophy or the presence of plus lesions and myopic choroidal neovascularization (mCNV) defined as CNV in the eye with PM. However, CNV in...
To describe the course of non-neovascular fluid in age-related macular degeneration (AMD) after anti-vascular endothelial growth factor (anti-VEGF) therapy or after observation without injections. see more
Conclusion: This study provides preliminary data regarding the progression of non-neovascular fluid in AMD with or without anti-VEGF injections. A possible mechanism for fluid development may be related to RPE pump impairment. Distinguishing neovascular versus non-neovascular fluid using multimodal imaging, including OCT angiography, is...
Introduction Retinal vein occlusion (RVO) is the second most common retinal vascular disorder, and cystoid macular edema (CME) is the main cause of vision loss in these patients. 1 Intravitreal ..... see more
Conclusion:This study suggests that SMD seems to be more frequent in patients with recurrent CME secondary to CRVO when compared to BRVO. The choice of initial intravitreal treatment with either ranibizumab or dexamethasone implant did not affect the prevalence of SMD in recurrent CME. However, longer-term prospective studies including a larger...
2022 Aug 18;15(8):1296-1304. doi: 10.18240/ijo.2022.08.11. 1 Department of Ophthalmology, Changhai Hospital, Shanghai 200433, China. 2 Department of Ophthalmology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China. ..... see more
The estimated prevalence of ERM was 7.0%, which was higher than that of previous reports using fundus photography only in an East Asian population. Possible risk factors for ERM were ..... see more
Conclusions: The estimated prevalence of ERM was 7.0%, which was higher than that of previous reports using fundus photography only in an East Asian population. Possible risk factors for ERM were older age, history of cataract surgery, hypertension, and diabetic retinopathy. This article is protected by copyright. All rights reserved.
Introduction Worldwide, diabetic retinopathy (DR) is one of the leading causes of vision loss. Early treatment and screening for DR have a major role in reducing the rate of the ..... see more
In this retrospective cohort study, the presence of intraretinal fluid was associated with poorer visual outcome in neovascular AMD patients treated with anti-VEGF, but the presence of subretinal fluid and ..... see more
Conclusion/Relevance: In this retrospective cohort study, the presence of intraretinal fluid was associated with poorer visual outcome in neovascular AMD patients treated with anti-VEGF, but the presence of subretinal fluid and PEDs was not. This suggests that IRF is worse than subretinal fluid and PEDs for AMD outcomes and therefore requires...
Purpose of Review Intravitreal anti-vascular endothelial growth factor (VEGF) agents are used routinely in the management of neovascular conditions including proliferative diabetic retinopathy and diabetic macular edema. While the efficacy ..... see more
Sodium butyrate-loaded nanoparticles coated chitosan (NaBu-loaded nanoparticles/CS) were developed to treat the choroidal neovascularization in wet age-related macular degeneration (AMD). The nanoparticles were produced by double emulsification and solvent evaporation ..... see more
Diabetic macular edema (DME), which manifests clinically as visual impairment, is a common complication of diabetes[ 1- 3]. Long-term high blood glucose is the basis of DME, as it causes ..... see more
Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly population. Anti-vascular endothelial growth factor (VEGF) antibody therapy is applicable to neovascularisation of AMD; however, the ..... see more
The purpose of this study was to provide an estimate of the number of current and future patients with polypoidal choroidal vasculopathy (PCV) in Europe. We systematically searched 11 literature ..... see more
To determine baseline visual acuity before the start of treatment for neovascular age-related macular degeneration (AMD), compare median and visual acuity states between treatment sites and investigate the association of ..... see more
Conclusions: Despite access to publicly funded treatment within the NHS, variation in visual acuity at the start of neovascular AMD treatment persists. Identifying the characteristics associated with poor baseline acuity, targeted health awareness campaigns, professional education, and pathway re-design may help to improve baseline acuity, the...