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The Effect of Sample Medication Use on Subsequent Anti-VEGF Agent Selection for Neovascular Age-Related Macular Degeneration

ABSTRACT Medication samples of anti-VEGF agents can represent a good option for retina specialists to provide timely treatment for newly converted neovascular age-related macular degeneration (nvAMD) while prior-authorizations (PA) are ..... see more

Source : https://www.tandfonline.com/doi/abs/10.1080/08820538.2022.2107398?journalCode=isio20


Conclusions: Sample medications in nvAMD may be initiated for many reasons, including awaiting PA approval. Our study found that eyes receiving a sample anti-VEGF agent (ranibizumab or aflibercept) for their initial injection were less likely to receive bevacizumab at future visits relative to eyes that did not receive an anti-VEGF sample,...

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Time course of changes in vision-related quality of life following intravitreal ranibizumab treatment for branch retinal vein occlusion - Scientific Reports

To evaluate the vision-related quality of life (VR-QOL) treated by intravitreal ranibizumab (IVR) in patients with branch retinal vein occlusion (BRVO) and to assess subscale items of the VR-QOL. This ..... see more

Source : https://www.nature.com/articles/s41598-022-17587-0


Relevance: To evaluate the vision-related quality of life (VR-QOL) treated by intravitreal ranibizumab (IVR) in patients with branch retinal vein occlusion (BRVO) and to assess subscale items of the VR-QOL.

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Reduction of Laser-Induced Choroidal Neovascularization in Mice With Erythropoietin RNA Interference

Wenjuan Lv, 1 , * Wen Chen, 1 , 2 , * Shaofen Huang, 1 Yanxuan Xu, 1 Jia-Jian Liang, 1 Yuqian Zheng, 1 Shaowan Chen, 1 Shao-Lang Chen, 1 ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351596/


Conclusions: This study revealed the promotion of human endothelial cell tube formation in vitro and choroid sprouting ex vivo by EPO, and the reduction of laser-induced CNV in vivo by Epo RNA interference.

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A prospective, randomized, parallel group, double blind, multicenter study to compare the efficacy, safety and immunogenicity of Lupin's Ranibizumab with Lucentis ® in patients with neovascular age-related macular degeneration - PubMed

1 Professor, Department of Ophthalmology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. 2 Vitreo Retinal Surgeon-Department of Ophthalmology, Rising Retina Clinic, Ahmedabad, Gujarat, India. 3 Consultant, Department ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35918962/


Conclusion: Lupin’s biosimilar ranibizumab demonstrated therapeutic equivalence, desirable safety, and favorable immunogenicity profile compared to Lucentis®.

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Guidance on brolucizumab management recommendations

Available online 23 July 2022 Brolucizumab, a new generation anti-VEGF, has demonstrated efficacy and safety in AMD in the pivotal HAWK and HARRIER trials. Post-marketing, previously undetected adverse events related ..... see more

Source : https://www.sciencedirect.com/science/article/abs/pii/S2173579422000846?via=ihub


Conclusion: The adverse events reported are rare, but may be associated with severe and irreversible loss of visual acuity. The recommendations made are intended to facilitate the management of brolucizumab in the routine practice of retinologists, to ensure patient safety and, should any adverse events occur, to minimise their impact on...

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Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE

Senescent cells have been demonstrated to have lower cellular NAD + levels and are involved in the development of various age-related diseases, including age-related macular degeneration (AMD). Sodium iodate (NaIO ..... see more

Source : https://www.hindawi.com/journals/omcl/2022/5961123/


Conclusion: Our results indicate that RPE senescence induced by NaIO3 acquired several key features of AMD. More importantly, NMN may potentially be used to treat RPE senescence and senescence-associated pre-AMD changes by restoring the NAD levels in cells and tissues.

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An Introduction to Biosimilars for the Treatment of Retinal Diseases: A Narrative Review - PubMed

Biological therapies have revolutionized the treatment of disease across a number of therapeutic areas including retinal diseases. However, on occasion, such treatments may be relatively more expensive compared to small ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35278204/


Conclusion: The current review provides an introduction to biosimilars with the aim of preparing retinal specialists for discussing these products with their patients.

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Innovator Versus Biosimilar Ranibizumab in Polypoidal Choroidal Vasculopathy: Real-World Evidence - Ophthalmology and Therapy

Introduction To analyze the efficacy and safety profile of the intravitreal ranibizumab biosimilar molecule, Razumab® (Intas Pharmaceuticals, Ahmedabad, India; BRm; Razumab®) and the innovator ranibizumab drug (IRm; LUCENTIS®) in Indian ..... see more

Source : https://link.springer.com/article/10.1007/s40123-022-00507-w


Conclusions: Our real-world data demonstrated the ranibizumab biosimilar Razumab to have comparable visual acuity outcomes to the innovator ranibizumab molecule with an adequate safety profile in the management of PCV. Although these encouraging results support its use as a viable alternative to the innovator molecule, further prospective...

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Evaluation of the Structural, Physicochemical, and Biological Characteristics of SB11, as Lucentis ® (Ranibizumab) Biosimilar - PubMed

Introduction: SB11 was recently approved as a ranibizumab biosimilar by the US Food and Drug Administration (FDA) and the European Commission (EC) as a therapy for retinal vascular disorders under ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35084693/


Conclusion: Based on the comprehensive analytical similarity assessment, SB11 is highly similar to the EU/US-ranibizumab with respect to structural, physicochemical, and biological properties.

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Dabigatran and Wet AMD, Results From Retinal Pigment Epithelial Cell Monolayers, the Mouse Model of Choroidal Neovascularization, and Patients From the Medicare Data Base

BackgroundAge-related macular degeneration (AMD), the leading cause of irreversible blindness in elderly Caucasian populations, includes destruction of the blood-retina barrier (BRB) generated by the retinal pigment epithelium-Bruch's membrane complex (RPE/BrM), ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2022.896274/full


Conclusions: This study provides evidence of association between dabigatran use and reduced exudative AMD diagnosis. Based on the cell- and animal-based studies, we suggest that thrombin modulates wound healing and CTGF and VEGF expression, making dabigatran a potential novel treatment option in AMD.

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Dust Storms Increase the Risk of Age-Related Macular Degeneration - PubMed

The main purpose of this study was to examine the association between dust storms (DSs) and age-related macular degeneration (AMD) using a 5 year representative national dataset with one million ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35742653/


Conclusion: Although AMD highly correlated with age, this study also found that dry AMD outpatient visits in people under the age of 50 were also found to be significantly associated with DS events. In order to protect the health of eyes and avoid AMD, one should reduce or avoid outdoor activities when DS events occur.

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Dry Eye and Meibomian Gland Dysfunction in Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Injections - PubMed

Multiple factors such as povidone-iodine and the preservatives in topical eye drops may cause inflammation leading to ocular surface damage in patients treated with multiple intravitreal injections. As the treatment ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35769012/


Conclusion: Multiple factors such as povidone-iodine and the preservatives in topical eye drops may cause inflammation leading to ocular surface damage in patients treated with multiple intravitreal injections. As the treatment requires repeated injections, exposure to these factors might worsen the ocular surface inflammation. The possibility...

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Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration

Age-Related Macular Degeneration (AMD) is a bilateral ocular condition resulting in irreversible vision impairment caused by the progressive loss of photoreceptors in the macula, a region at the center of ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244395/


Relevance: This study provides new observations for retina age clocks and suggests new applications for monitoring in vitro neuronal differentiation. These clocks could provide useful markers for AMD monitoring and possible intervention, as well as potential targets for in vitro screens.

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Severity of age-related macular degeneration at first presentation in Bhutan: a 3-year national study - BMC Ophthalmology

Background Medical services are still developing in Bhutan. There is no published national report on age-related macular degeneration (AMD). We therefore aim to determine the demographic characteristics and severity of ..... see more

Source : https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-022-02520-w


Conclusions: Half of nAMD cases presented as DS not amenable to the treatment. Many potentially treatable nAMD patients had already lost central vision and were legally blind. Young people with PCV losing vision early in life with longer morbidity-affected life and socio-economic burden was concerning. GA and DS cases need visual...

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The Association of Fluid Volatility With Subretinal Hyperreflective Material and Ellipsoid Zone Integrity in Neovascular AMD - PubMed

Greater volatility in exudative OCT metrics, particularly SRF volatility, was associated with a greater increase in SHRM and less improvement in EZ integrity, suggesting that volatility is detrimental to multiple ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35713892/


Conclusions: Greater volatility in exudative OCT metrics, particularly SRF volatility, was associated with a greater increase in SHRM and less improvement in EZ integrity, suggesting that volatility is detrimental to multiple anatomic features in nAMD. Early exudative instability during the loading phase of treatment was associated with...

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Lower CXCR3 expression in both patients with neovascular AMD and advanced stages of chronic myeloproliferative blood cancers

Purpose Peripheral T cell CXCR3 expression has been found uniquely lower in patients having neovascular age-related macular degeneration (nAMD) than in healthy individuals. The CXCR3-axis has been shown to have ..... see more

Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269960


Conclusions: We find CXCR3 downregulation on T-cells and some monocyte subset in nAMD compared to iAMD, MPNd, and MPNn, in line with previous nAMD studies. We also find CXCR3 downregulation in most monocyte subsets over the MPN continuum. Systemic leukocyte CXCR3 expression could both be involved in changes seen in the retina and the bone...

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Projected US Savings From Biosimilars, 2021-2025

Objectives: Biologics account for an increasing share of US prescription drug spending. Biosimilars could lower biologic prices through competition, but barriers to increasing both supply and uptake remain. We projected ..... see more

Source : https://www.ajmc.com/view/projected-us-savings-from-biosimilars-2021-2025


Conclusions: Biosimilar savings from 2021 to 2025 were $38.4 billion under our main assumptions. Greater savings may be feasible if managed care and other settings increase biosimilar utilization and promote competition.

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NURR1 expression regulates retinal pigment epithelial-mesenchymal transition and age-related macular degeneration phenotypes - PubMed

Phenotypic variations in the retinal pigment epithelial (RPE) layer are often a predecessor and driver of ocular degenerative diseases, such as age-related macular degeneration (AMD), the leading cause of vision ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35867766/


Conclusion/Relevance: These results provide insight into the mechanisms of action of NURR1 in the aging eye, and demonstrate that the relative expression levels and activity of NURR1 is critical for both physiological and pathological functions of human RPE cells through RXRα-dependent regulation, and that targeting NURR1 may have therapeutic...