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Risk factors for myopic choroidal neovascularization-related macular atrophy after anti-VEGF treatment

Purpose The study aimed to evaluate risk factors for macular atrophy (MA) associated with myopic choroidal neovascularization (mCNV) during long-term follow-up after intravitreal anti-vascular endothelial growth factor (VEGF) treatment in ..... see more

Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0273613


Conclusions: In mCNV eyes treated with intravitreal anti-VEGF agents, older age and greater mCNV size at baseline were risk factors for the development of MA during long-term follow-up, which was associated with a poor visual prognosis.

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Efficacy and Safety of Aflibercept Therapy for Diabetic Macular Edema: A Systematic Review and Meta-Analysis - PubMed

1 Faculty of Medicine, McGill University, Montreal, Canada. 2 Department of Ophthalmology, Faculty of Medicine, McGill University, Montreal, Canada. 3 Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36147265/


Conclusions: Aflibercept is a safe and effective therapy option for DME in the clinical setting, performing superiorly to laser photocoagulation. Evidence regarding comparisons with bevacizumab, ranibizumab, and dexamethasone is mixed and limited.

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Short-term outcomes of switching to brolucizumab in japanese patients with neovascular age-related macular degeneration - Japanese Journal of Ophthalmology

Purpose To evaluate the outcomes of a 6-month follow-up after switching to brolucizumab from aflibercept to treat neovascular age-related macular degeneration (AMD) in Japanese patients. Study design Retrospective observational study. ..... see more

Source : https://link.springer.com/article/10.1007/s10384-022-00940-1


Conclusion: Switching to brolucizumab from aflibercept using a TAE regimen might be effective for maintaining functional outcomes and extending intervals in Japanese patients with AMD.

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Hyperreflective Membrane at the Vitreoretinal Interface in Diabetic Macular Edema: A Finding in Ultra-High-Resolution Optical Coherence Tomography - PubMed

1 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 2 Department of Ophthalmology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan. 3 Clinical Research Institute, National ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36149646/


Conclusion/Relevance: Detecting subtle vitreoretinal interface (VRI) findings, such as a posterior hyaloid membrane, is difficult with conventional retinal imaging. We compared ultra-high-resolution spectral domain optical coherence tomography (UHR-SD-OCT) with standard-resolution OCT (SD-OCT) for the imaging of VRI abnormalities in diabetic...

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Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy: Longitudinal Evaluation in Age-Related Macular Degeneration

To examine the association between incomplete retinal pigment epithelial and outer retinal atrophy (iRORA) on optical coherence tomography (OCT) imaging and the subsequent risk of developing geographic atrophy (GA) defined ..... see more

Source : https://www.aaojournal.org/article/S0161-6420(22)00691-1/fulltext


Conclusions: In this cohort, iRORA is a significant risk factor for GA development, but its association with GA development appears to be accounted for by the development of the specific features that define nGA. Whilst requiring replication, these findings provide useful guidance on the relative utility of nGA and iRORA as risk factors for GA...

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OCT Analysis of Retinal Pigment Epithelium in Myopic Choroidal Neovascularization: Correlation Analysis with Different Treatments - PubMed

Objective : The objective of this study was to analyze the status of the retinal pigment epithelium (RPE) by means of the spectral domain optical coherence tomography (SD-OCT) overlying the ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36078952/


Conclusions: Our results showed that the size of myopic neovascular lesion influences the development of a uniform RPE above the lesion and therefore the disease prognosis. The presence of uniform RPE was found to be extremely important in the follow-up of patients with myopic CNV, as it influences the duration of the disease and the number of...

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Characteristics of choroidal neovascularization in elderly eyes with high myopia not meeting the pathologic myopia definition - Scientific Reports

The META-Analysis of Pathologic Myopia Study group proposed a new classification system for myopic maculopathy (MM) with pathologic myopia (PM) defined as MM equal to/more serious than diffuse atrophy or ..... see more

Source : https://www.nature.com/articles/s41598-022-18074-2


Relevance: The META-Analysis of Pathologic Myopia Study group proposed a new classification system for myopic maculopathy (MM) with pathologic myopia (PM) defined as MM equal to/more serious than diffuse atrophy or the presence of plus lesions and myopic choroidal neovascularization (mCNV) defined as CNV in the eye with PM. However, CNV in...

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Course of non-neovascular fluid in age-related macular degeneration: observe and extend regimen in a case-series study

To describe the course of non-neovascular fluid in age-related macular degeneration (AMD) after anti-vascular endothelial growth factor (anti-VEGF) therapy or after observation without injections. see more

Source : https://www.canadianjournalofophthalmology.ca/article/S0008-4182(22)00251-4/fulltext


Conclusion: This study provides preliminary data regarding the progression of non-neovascular fluid in AMD with or without anti-VEGF injections. A possible mechanism for fluid development may be related to RPE pump impairment. Distinguishing neovascular versus non-neovascular fluid using multimodal imaging, including OCT angiography, is...

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Prevalence of Serous Macular Detachment in Recurrent Macular Edema Secondary to Retinal Vein Occlusion

Introduction Retinal vein occlusion (RVO) is the second most common retinal vascular disorder, and cystoid macular edema (CME) is the main cause of vision loss in these patients. 1 Intravitreal ..... see more

Source : https://www.oftalmoloji.org/archives/archive-detail/article-preview/prevalence-of-serous-macular-detachment-in-recurre/52726


Conclusion:This study suggests that SMD seems to be more frequent in patients with recurrent CME secondary to CRVO when compared to BRVO. The choice of initial intravitreal treatment with either ranibizumab or dexamethasone implant did not affect the prevalence of SMD in recurrent CME. However, longer-term prospective studies including a larger...

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Anti-VEGF reduces inflammatory features in macular edema secondary to retinal vein occlusion - PubMed

2022 Aug 18;15(8):1296-1304. doi: 10.18240/ijo.2022.08.11. 1 Department of Ophthalmology, Changhai Hospital, Shanghai 200433, China. 2 Department of Ophthalmology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36017031/


Conclusion: Anti-VEGF therapy is effective in treating RVO-ME. The mechanisms for the decreased HRF and the reduction of NPA by anti-VEGF therapy merits further exploration.

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Prevalence and risk factors of epiretinal membrane: Data from the Korea National Health and Nutrition Examination Survey VII (2017-2018) - PubMed

The estimated prevalence of ERM was 7.0%, which was higher than that of previous reports using fundus photography only in an East Asian population. Possible risk factors for ERM were ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36073108/


Conclusions: The estimated prevalence of ERM was 7.0%, which was higher than that of previous reports using fundus photography only in an East Asian population. Possible risk factors for ERM were older age, history of cataract surgery, hypertension, and diabetic retinopathy. This article is protected by copyright. All rights reserved.

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Effect of the COVID-19 Pandemic Lockdown on the Management of Diabetic Retinopathy: A Cross-Sectional Study

Introduction Worldwide, diabetic retinopathy (DR) is one of the leading causes of vision loss. Early treatment and screening for DR have a major role in reducing the rate of the ..... see more

Source : https://www.cureus.com/articles/102216-effect-of-the-covid-19-pandemic-lockdown-on-the-management-of-diabetic-retinopathy-a-cross-sectional-study


Conclusions: COVID-19 has severely impacted the routine follow-up of DR and, in the subsequent years, there might be an increased incidence of severe outcomes due to DR. The second wave of COVID-19 and its lockdown have had very significant effects on the visual outcome of untreated DR patients.

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Association between structural and functional treatment outcomes in neovascular age-related macular degeneration - PubMed

In this retrospective cohort study, the presence of intraretinal fluid was associated with poorer visual outcome in neovascular AMD patients treated with anti-VEGF, but the presence of subretinal fluid and ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36036674/


Conclusion/Relevance: In this retrospective cohort study, the presence of intraretinal fluid was associated with poorer visual outcome in neovascular AMD patients treated with anti-VEGF, but the presence of subretinal fluid and PEDs was not. This suggests that IRF is worse than subretinal fluid and PEDs for AMD outcomes and therefore requires...

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Systemic and Ocular Adverse Events with Intravitreal Anti-VEGF Therapy Used in the Treatment of Diabetic Retinopathy: a Review - Current Diabetes Reports

Purpose of Review Intravitreal anti-vascular endothelial growth factor (VEGF) agents are used routinely in the management of neovascular conditions including proliferative diabetic retinopathy and diabetic macular edema. While the efficacy ..... see more

Source : https://link.springer.com/article/10.1007/s11892-022-01491-y


Summary: Intravitreal anti-VEGF therapy is used in the treatment of diabetic retinopathy, macular degeneration, and other diseases. These agents are associated with a variety of ocular and systemic adverse events that ophthalmologists should always consider.

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Sodium butyrate-loaded nanoparticles coated with chitosan for the treatment of neovascularization in age-related macular degeneration: Ocular biocompatibility and antiangiogenic activity

Sodium butyrate-loaded nanoparticles coated chitosan (NaBu-loaded nanoparticles/CS) were developed to treat the choroidal neovascularization in wet age-related macular degeneration (AMD). The nanoparticles were produced by double emulsification and solvent evaporation ..... see more

Source : https://www.sciencedirect.com/science/article/abs/pii/S0939641122001783?via=ihub


Relevance: Sodium butyrate-loaded nanoparticles coated chitosan (NaBu-loaded nanoparticles/CS) were developed to treat the choroidal neovascularization in wet age-related macular degeneration (AMD).

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Efficacy and mechanism of anti-vascular endothelial growth factor drugs for diabetic macular edema patients

Diabetic macular edema (DME), which manifests clinically as visual impairment, is a common complication of diabetes[ 1- 3]. Long-term high blood glucose is the basis of DME, as it causes ..... see more

Source : https://www.wjgnet.com/1948-9358/full/v13/i7/532.htm


Conclusion: Anti-VEGF drugs can effectively improve CMT and SFCT, without affecting microcirculation, thus providing an effective and safe treatment for patients with DME.

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Alpinumisoflavone ameliorates choroidal neovascularisation and fibrosis in age-related macular degeneration in in vitro and in vivo models - Scientific Reports

Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly population. Anti-vascular endothelial growth factor (VEGF) antibody therapy is applicable to neovascularisation of AMD; however, the ..... see more

Source : https://www.nature.com/articles/s41598-022-18531-y


Conclusion/Relevance: We report the anti-fibrotic and anti-neovascularisation effects of alpinumisoflavone (AIF), an isoflavonoid derived from unripe Maclura tricuspidata fruit, in in vitro and in vivo models.

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European Prevalence of Polypoidal Choroidal Vasculopathy: A Systematic Review, Meta-Analysis, and Forecasting Study - PubMed

The purpose of this study was to provide an estimate of the number of current and future patients with polypoidal choroidal vasculopathy (PCV) in Europe. We systematically searched 11 literature ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36013005/


Relevance: The purpose of this study was to provide an estimate of the number of current and future patients with polypoidal choroidal vasculopathy (PCV) in Europe.

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Associations with baseline visual acuity in 12,414 eyes starting treatment for neovascular AMD - Eye

To determine baseline visual acuity before the start of treatment for neovascular age-related macular degeneration (AMD), compare median and visual acuity states between treatment sites and investigate the association of ..... see more

Source : https://www.nature.com/articles/s41433-022-02208-x


Conclusions: Despite access to publicly funded treatment within the NHS, variation in visual acuity at the start of neovascular AMD treatment persists. Identifying the characteristics associated with poor baseline acuity, targeted health awareness campaigns, professional education, and pathway re-design may help to improve baseline acuity, the...