Effect of repeated intravitreal anti-vascular endothelial growth factor drugs on corneal nerves
ation (AMD), 20 cases of diabetic macular edema (DME) and 25 cases of retinal vein occlusion (RVO). Twenty-nine cases were treated with aflibercept (2 mg/0.05 mL) whereas 35 cases were managed with...
Conclusions/Relevance: Repeated intravitreal anti-VEGF drug can reduce the length of corneal nerves. For patients who need repeated intravitreal injections of anti-VEGF drugs, especially in DM, attention should be paid on the changes affecting the corneal nerves. It is also needed to strengthen the local anti-inflammatory therapy to avoid...
Regulatable Complement Inhibition of the Alternative Pathway Mitigates Wet Age-Related Macular Degeneration Pathology in a Mouse Model - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37462980/
The goal of anticomplement therapy is to restore homeostatic levels of complement activation, which might be more easily achievable using a self-regulating system.
Conclusions: We conclude that complement-dependent regulation of AP inhibition ameliorates AMD pathology as effectively as using a constitutive promoter.
Family History of AMD and Genetics Predict Progression to Advanced AMD Adjusting for Macular Status, Demographic and Lifestyle Factors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37437830/
Genetic variants and family history provided additional discrimination for AAMD prediction, after accounting for ocular and other covariates.
Conclusion: Genetic variants and family history provided additional discrimination for AAMD prediction, after accounting for ocular and other covariates.
Optical coherence tomography angiography biomarkers in a bi-monthly maintenance dosing aflibercept in patients with neovascular age-related macular degeneration - BMC Ophthalmology
Source : https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-023-03039-4
Purpose To evaluate the correlations between swept-source optical coherence tomography angiography (SS-OCTA) parameters and clinical outcomes in eyes with neovascular age-related macular degeneration (nAMD) administered a bimonthly intravitreal aflibercept regimen....
Conclusions: The decrease in mean VD during the loading phase was significantly negatively correlated with the final BCVA at the last visit. The decrease in mean VLD during the loading phase, mean CST during the loading phase, and the improvement in final BCVA showed significant correlations. Therefore, early changes in OCTA microvascular and...
Geographic variation in diabetic retinopathy screening within the Veterans Health Administration - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37419770/
The wide variability in DR screening across 125 VA catchment areas indicates the presence of unmeasured determinants of DR screening. These results are relevant to clinical decision making in DR...
Conclusions: The wide variability in DR screening across 125 VA catchment areas indicates the presence of unmeasured determinants of DR screening. These results are relevant to clinical decision making in DR screening resource allocation.